Peculiarities of the different types of Diabetes.

Cellular immunological mechanisms of Type 1 Diabetes

Type-1 diabetes (T1D) –or insulin-dependent diabetes– is an autoimmune disorder caused by pancreatic damage, which subsequently fails to produce insulin.  This type of diabetes –usually of juvenile onset– may be caused by a genetic predisposition –disorder in HLA loci– or as result of the immune-mediated destruction of insulin-producing pancreatic β-cells by antigen-specific T-cells.