After une petite IT glitch in le matrix the session “Compounding without frontiers, cooperation over country borders” commenced with Professor Koch outlining some of her research in the area of Therapeutic Drug Monitoring (TDM) and Model Informed Precision Dosing (MIPD) and the benefits of collaborating with other global experts. TDM and MIPD are tools to allow personalised dosing/pharmaceutical care which is a holy grail of clinical pharmacists. Apart from the clinical benefits of optimal dosing to match the unique physiology and biochemistry of a patient there are also financial and sustainability benefits too. Instead of one (or repeated) doses for every patient, as recommended by the manufacturer/ SmPC, tailored doses can result in less medication being administered for the same benefit and a reduced side-effects burden. This can mean increased patient access to rare and/or expensive medications and financial savings. Brilliant! you say, why aren’t we all using TDM? Well, interestingly, the good professor also shared with us two studies that showed no benefits in primary and secondary outcomes between patients treated sans TDM (apart from adjustments for eGFR) and those who were. Some of the details can be found in the Dolphin Trial conducted in the Netherlands). However, collaboration came to the rescue. Other experts and researchers were able to contribute to the discussion and it seems there are important benefits to be obtained in subsets of the patients involved in the study. Professor Koch indicated that larger studies are required to verify the benefits of TDM and MIPD. TDM, According to the professor TDM may become more easily accessible to clinical pharmacists as there are now biosensors for medicines that could simplify the sampling/ analytical aspect of TDM but further validation of the benefits of expanded TDM services is required. Professor Koch also spoke about the EU’s ambition “to create new knowledge and scientific evidence and to codesign new solutions and support their transfer and scale-up across countries and regions while also fostering capacity building.” (EU text and my italics). Interested parties can also liaise directly with the professors university at COST.bEU.PREPAREDNESS@ ERASMUSMC.NL
For verified healthcare professionals
Log in or register for free to read this article. HPN is for healthcare professionals, so new accounts are verified by our team.
