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Glucocorticoids are currently an indispensable part of the treatment approach to a wide variety of medical conditions. While generally extremely effective, at least temporarily, the multitude of attendant adverse events associated with glucocorticoid use should see them viewed as “our best of drugs, our worst of drugs”. These adverse events included hypertension, diabetes mellitus, infection, weight gain, in addition to muscle weakness. And also of particular relevance to the current conversation, osteoporosis and increased fracture risk.1
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